吴嘉炜 博士


教授，博导，国家杰出青年基金获得者

1990-1994，南京大学 学士

1994-1999，中国科学院生物物理研究所 博士

1999-2003，普林斯顿大学分子生物学系，博士后，研究助理

现为清华大学教授

主要科研领域与方向：

■ 生物大分子的X-射线晶体学研究

■ 分子结构基础上的蛋白质相互作用

■ 蛋白质功能的物理化学研究

Selected Publications:

■ Chai J, Wu JW, Yan N, Massague J, Pavletich NP, Shi Y. Features of a Smad3 MH1-DNA complex. Roles of water and zinc in DNA binding. J Biol Chem. 2003 May 30; 278(22): 20327-31.

■ Wu JW, Krawitz AR, Chai J, Li W, Zhang F, Luo K, Shi Y. Structural mechanism of Smad4 recognition by the nuclear oncoprotein Ski: insights on Ski-mediated repression of TGF-beta signaling. Cell. 2002 Nov 1; 111(3): 357-67.

■Wu JW, Hu M, Chai J, Seoane J, Huse M, Li C, Rigotti DJ, Kyin S, Muir TW, Fairman R, Massague J, Shi Y. Crystal structure of a phosphorylated Smad2. Recognition of phosphoserine by the MH2 domain and insights on Smad function in TGF-beta signaling. Mol Cell. 2001 Dec; 8(6): 1277-89.

■ Wu JW, Cocina AE, Chai J, Hay BA, Shi Y. Structural analysis of a functional DIAP1 fragment bound to grim and hid peptides. Mol Cell. 2001 Jul; 8(1): 95-104.

■ Wu JW, Fairman R, Penry J, Shi Y. Formation of a stable heterodimer between Smad2 and Smad4. J Biol Chem. 2001 Jun 8; 276(23): 20688-94. Epub 2001 Mar 27.

■ Chai J, Du C, Wu JW, Kyin S, Wang X, Shi Y. Structural and biochemical basis of apoptotic activation by Smac/DIABLO. Nature. 2000 Aug 24; 406(6798): 855-62.

■ Wu JW, Wang ZX. New evidence for the denaturant binding model. Protein Sci. 1999 Oct; 8(10):2090-7.

■ Wu JW, Wang ZX. Activation mechanism and modification kinetics of Chinese hamster dihydrofolate reductase by p-chloromercuribenzoate. Biochem J. 1998 Oct 1; 335 (Pt 1): 181-9.

■ Wu JW, Wang ZX, Zhou JM. Inactivation kinetics of dihydrofolate reductase from Chinese hamster during urea denaturation. Biochem J. 1997 Jun 1; 324 (Pt 2): 395-401.